The Travel center includes a casino area with 45 slot machines. Excite. Saturdays in. DISCOVER NORTHERN NEW MEXICO AT ITS BEST! The casino is open every day. at Isleta Resort & Casino. New Mexico has 23 Indian casinos and 4 Indian gaming travel centers located across 10 counties. . These casinos and gaming sites are owned by 14 New Mexico. It's a warm, friendly environment with slot machines. Read More! Sky City's Main Casino and the Travel Center's Slot Area is open 24 hours daily. Colorful bingo cards and round bingo balls w/numbers. #1 Best Value of 24 Mexico Casino Hotels ; 2. 1. Win. Indulge. A warm and friendly environment with slot machines at the Main Casino. The Pyramid Cancun · 4, reviews. Experience Vegas at Albuquerque's Sandia Casino! Test your luck at our slots or play poker, roulette & more! High limit & VIP lounge available. Unwind. Seadust Cancun Family Resort · 6, reviews. Must be 21+. Our New Mexico casino is open 24/7 daily. Swirls of Cash. #2 Best Value of 24 Mexico. No Smoking Facility. Learn More. With three live entertainment venues, you'll find something around every corner. Upcoming Events. Open 24 hours, 7 days a week! What's happening. Sunday - Thursday: 8 AM - 2 AM | Friday & Saturday: Join the fun at Santa Ana Star Casino Hotel, the best casino in New Mexico! Located just north of Albuquerque, NM, we offer Gaming, Bowling, Golf, Dining. Sky City Casino is open 24 hours daily.