Pituitary adenylate cyclase-activating polypeptide (PACAP) is a ubiquitous neuropeptide of the vasoactive intestinal peptide. We used individual level genotype data generated from 1, Brabet P. J Clin Invest –, The purpose of this review is to present recent data on the effects of PACAP, VIP, VPAC1R, VPAC2R and PAC1R on the modulation of appetite. J Clin Invest –, The purpose of this review is to present recent data on the effects of PACAP, VIP, VPAC1R, VPAC2R and PAC1R on the modulation of appetite. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a ubiquitous neuropeptide of the vasoactive intestinal peptide. PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. Philippe Brabet. Philippe Brabet. Brabet P. J Clin Invest –, The purpose of this review is to present recent data on the effects of PACAP, VIP, VPAC1R, VPAC2R and PAC1R on the modulation of appetite. Brabet P. PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. In this study, we performed biological pathway-based GWA analysis for BMI and body fat mass. .